Matrix Gla-Protein (MGP) Not Only Inhibits Calcification in Large Arteries But Also May Be Renoprotective: Connecting the Dots
نویسنده
چکیده
Article history: Received 19 January 2016 Accepted 19 January 2016 Available online 21 January 2016 cardiovascular outcomes, and mortality (Liu et al., 2015). MGP acts as a strong inhibitor of soft tissue calcification. As an illustration, MGP knockout mice develop massive vascular calcification in their first weeks of life and die within 2 months of vessels' rupture (Luo et al., 1997). To acquire its full calcification inhibitory activity, MGP needs to
منابع مشابه
Novel conformation-specific antibodies against matrix gamma-carboxyglutamic acid (Gla) protein: undercarboxylated matrix Gla protein as marker for vascular calcification.
OBJECTIVE Matrix gamma-carboxyglutamic acid (Gla) protein (MGP), a vitamin K-dependent protein, is a potent in vivo inhibitor of arterial calcification. We hypothesized that low endogenous production of MGP and impaired carboxylation of MGP may contribute to the development or the progression of vascular disease. METHODS AND RESULTS Novel conformation-specific antibodies against MGP were used...
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Background and purpose: Coronary artery stenosis is a progressive process associated with artery calcification. Although the role of matrix Gla protein (MGP) is not completely clear but its expression in vascular smooth muscle cells (VSMCs) and sub-endothelial macrophages suggests a role in vascular calcification. The rs1800799 is one of the polymorphisms oriented within transcription factor el...
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عنوان ژورنال:
دوره 4 شماره
صفحات -
تاریخ انتشار 2016